Table 1 Demographic characteristics and cytokines levels of participants

From: Relationship between white matter integrity and serum inflammatory cytokine levels in drug-naive patients with major depressive disorder: diffusion tensor imaging study using tract-based spatial statistics

 

Healthy subjects

(n = 35)

MDD patients

(n = 35)

p-value

t-value

degrees of freedom

Characteristics

Age, years; mean, (range, SD)

44.0 (20–65, 11.4)

46.3 (20–73, 14.3)

0.463

−7.38

64.9

Female, numbers

13

17

0.469

  

Obesity, %

2 (6.1)

2 (6.1)

1.000

  

Medical comorbidities

Hypertension, %

2 (5.7)

8 (22.9)

0.084

  

Hyperlipidemia, %

6 (17.1)

12 (34.3)

0.171

  

Diabetes mellitus, %

0 (0)

1 (2.9)

1.000

  

HAMD-17, mean of total scores (SD)

 

21.0 (6.0)

   

Inflammatory, mean; pg/mL (SD)

IL-1β

0.058 (0.098)

0.038 (0.044)

0.411

1.094

 

IL-6

0.410 (0.364)

0.616 (0.812)

0.152

1.368

 

IFN-γ

8.969 (15.225)

10.455 (15.861)

0.111

0.400

 

TNF-α

2.336 (6.239)

1.612 (0.598)

0.339

0.684

 
  1. Diabetes mellitus defined as a random glucose level of >11.1 mmol/l, fasting blood glucose > 7.0 mmol/l, HbA1c > 6.5%, or the current use of antidiabetic drugs, hypertension (blood pressure > 140/90 mm Hg or current treatment with antihypertensive drugs), dyslipidemia (LDL cholesterol > 3.64 mmol/l, HDL cholesterol 0.91 mmol/l, triglyceride > 1.7 mmol/l, or treatment for dyslipidemia), and obesity (body mass index > 26 kg/m2)
  2. SD standard deviation, MDD major depression disorders, HAMD-17 17-item Hamilton Rating Scale for Depression, IL interleukin, IFN interferon, TNF tumor necrosis factor
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