Fig. 1: ANK3 gene and protein structure.
From: Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder
a Domain structure of the main isoforms of the Ankyrin-G protein with an orientation that matches the exonic structures in b and with the position of the “little” exon (ENSE00001786716) highlighted. The term “neuronal” exon is historical and perhaps a misnomer since recent data suggests that the short form of the “neuronal” exon is expressed in oligodendrocytes. b Summary of the exonic structure of ANK3 based on the five transcripts in the RefSeq database. Gray shading between a and b depicts the exon to domain mapping. c ANK3’s interaction partners at the node and paranode in the central nervous system14,45,46. Cntn contactin, Caspr contactin-associated protein, NF neurofascin, Nav voltage-gated sodium channel, 4.1B protein 4.1B. Little exon in pink, medium exon in green
