Fig. 5: Neuroinflammation in Gabrb2 KO mice. | Translational Psychiatry

Fig. 5: Neuroinflammation in Gabrb2 KO mice.

From: Gabrb2-knockout mice displayed schizophrenia-like and comorbid phenotypes with interneuron–astrocyte–microglia dysregulation

Fig. 5

Coronal sections were stained through fluorescence-labeling of Iba1 on microglia in: a CA1 of hippocampus; b dentate gyrus (DG); c anterior cingulate cortex (ACC); d central amygdaloid nucleus (CEA); e piriform cortex (PC); and f primary motor cortex (PMC). In (a–f), the number of Iba1-positive cells in WT or KO was estimated from five randomly selected images for each of five WT or KO males. Brain levels of g MDA (WT male n = 10, HT male n = 12, KO male n = 10), h TNF-α (WT, HT, and KO males, n = 6 in each group) and i IL-6 (WT, HT, and KO males, n = 6 in each group) were measured and expressed per mg protein of sample analyzed. Statistical analysis was performed using unpaired t-test for immunohistochemical measurements and one-way ANOVA with Newman–Keuls post-hoc test for the biochemical measurements; WT is represented by green dots, HT by orange dots, and KO by red dots. Average y values ± SEM in the different plots are represented by horizontal bars; *p < 0.05, **p < 0.01, ***p < 0.001

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