Table 1 Demographic characteristics of the recruited subjects

From: Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics study

Variables

Cohort 1

Cohort 2

 

HC

MDD

Pa

HC

MDD

BD

Pa

Sample size

50

50

–

40

49

30

–

Sex (M/F)

25/25

24/26

0.841

22/18

23/26

13/17

0.593

Age (years) b

36.9±1.3

38.3±1.6

0.503

36.8±1.6

37.7±1.7

35.8±10.7

0.249

BMIb

22.4±0.73

22.0±0.39

0.553

21.7±0.7

22.5±0.7

22.4±3.4

0.264

HDRS scores

0.4±0.1

24.6±0.5

<0.01

0.3±0.1

23.3±0.5

16.7±10.5

<0.01

BD-I

–

–

–

–

–

18

–

BD-II

–

–

–

–

–

12

–

Course (Month)

–

17.4±2.2

–

–

41.6±9.8

64.9±15.1

–

Medication (Y/N)

N

N

–

–

38/11

19/11

–

SSRI(Y/N)

N

N

–

N

29/20

10/20

–

SNRI (Y/N)

N

N

–

N

9/40

N

–

Mood stabilizers (Y/N)

N

N

–

N

N

5/25

–

Atypical antipsychotics(Y/N)

N

N

–

N

N

4/26

–

  1. HC healthy controls, MDD major depressive disorder, BD bipolar disorder, Y/N Yes/No, M/F male/female, HDRS Hamilton depression rating scale, BMI body mass index, SSRI selective serotonin reuptake inhibitors, SNRI serotonin noradrenalin reuptake inhibitors
  2. a Two-tailed Student’s test or one-way ANOVA for continuous variables (age, BMI, and HDRS scores); Chi-square analysis was used for categorical variables (sex)
  3. b Values were expressed as mean ± SEM
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