Table 2 Concentration (ng/g) of plasma neurometabolites in cohort 1

From: Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics study

Metabolites

Platform

Metabolic pathway

MDD

HC

Log2(FC)

p-value

SA

GC-MS

GABAergic

922.40±37.34

1083.14±48.10

−0.23

0.01

GABA

GC-MS

GABAergic

373.45±2.50

335.89±3.18

0.15

0.000

α-KG

GC-MS

GABAergic

10253.24±460.18

12863.54±897.06

−0.33

0.012

Gln

GC-MS

GABAergic

33032.90±2249.47

51223.80±2949.99

−0.63

0.000

Glu

GC-MS

GABAergic

15246.52±1107.83

14274.68±1024.47

0.10

0.521

Orn

GC-MS

GABAergic

15908.58±824.00

14520.46±801.36

0.13

0.23

l-Tyr

GC-MS

Catecholaminergic

8755.64±379.78

10224.73±527.16

−0.22

0.026

Tyra

LC-MS/MS

Catecholaminergic

19.26±4.30

1.98±0.33

3.28

0.000

DOPN

LC-MS/MS

Catecholaminergic

1.01±0.16

0.28±0.04

1.86

0.000

L-DOPA

GC-MS

Catecholaminergic

153.67±3.75

145.16±3.28

0.08

0.091

l-Phe

GC-MS

Catecholaminergic

10508.21±355.70

9671.28±538.41

0.12

0.198

HA

LC-MS/MS

Catecholaminergic

56.11±4.13

52.85±3.50

0.09

0.549

Trp

GC-MS

Serotonergic

591.01±45.51

902.68±89.38

−0.61

0.002

Kyn

LC-MS/MS

Serotonergic

1571.31±116.29

1992.25±78.81

−0.34

0.004

3-HA

GC-MS

Serotonergic

819.20±30.63

802.80±38.78

0.03

0.741

5-HT

LC-MS/MS

Serotonergic

140.27±28.80

186.63±79.81

−0.41

0.586

5-HIAA

LC-MS/MS

Serotonergic

21.30±2.03

18.31±1.17

0.22

0.206

NAS

LC-MS/MS

Serotonergic

0.77±0.11

0.85±0.11

−0.15

0.593

Tra

LC-MS/MS

Serotonergic

1.64±0.22

1.44±0.11

0.19

0.430

  1. A negative log2 (FC) indicates significantly lower expression in MDD subjects compared with healthy controls. A positive log2 (FC) indicates significantly higher expression in MDD subjects compared with healthy controls
  2. The data were analyzed using one-way ANOVA followed by Bonferroni’s post hoc test
  3. Values in bold denote statistically significant differences (p < 0.05)
  4. SA succinic acid, GABA γ-aminobutyric acid, a-KG α-ketoglutaric acid, Gln glutamine, Glu glutamic acid, Orn ornithine, l-Tyr l-tyrosine, Tyra tyramine, DOPN dopamine, L-DOPA L -3,4-dihydroxyphenylalanine, l-Phe l-phenylalanine, HA homovanillic acid, Trp tryptophan, Kyn kynurenine, 3-HA 3-hydroxyanthranilic acid, 5-HT 5-hydroxytryptamine, 5-HIAA 5-hydroxyindoleacetic acid, NAS N-acetyl-serotonin, Tra tryptamine
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