Fig. 4: Bioinformatic analysis of differentially expressed genes in Drd2 population following fear conditioning. | Translational Psychiatry

Fig. 4: Bioinformatic analysis of differentially expressed genes in Drd2 population following fear conditioning.

From: Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction

Fig. 4

a Enrichment analysis for the MetaCore Gene Ontology Processes identifies highly significant processes related to gene changes in Drd2 neurons. b Enrichment analysis for the MetaCore Gene Ontology Diseases identifies highly significant diseases related to gene changes in Drd2 neurons. c Weighted Network of genetically annotated transcripts showing differential gene expression. Differentially expressed transcripts were analyzed with the GeneMania Cytoscape plug-in using the default setting, but without extending the network with additional nodes. Genes that were not connected with others are not represented. The node size represents the −log(FDR-adjusted p-value), while the intensity of the color represents logFC (red nodes denote upregulation in FC, while blue nodes denote downregulation). The between-nodes edges represent relationships, the color of the edges represent the type of the relationship (76.5% co-expression in purple, 22% physical interactions in pink, 1.5% common pathway interactions in light blue), and the thickness of the edges denotes weight (i.e., strength of the pairwise relationship)

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