Table 1 Vigilance states, NREM and REM sleep episodes in Gria1−/− and wild-type mice (Gria1 + / + )

From: Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders

 

Gria1   +  /  + 

Gria1 -/-

BASELINE

WAKING

NREMS

REMS

NREM episodes

REM episodes

WAKING

NREMS

REMS

NREM episodes

REM episodes

Light

31.9 (2.0)

54.5 (2.3)

10.4 (0.6)

79.3 (4.7)

84.1 (7.2)

41.8 (4.4) a

47.8 (3.7)

8.1 (0.6)°

60.3 (4.2) a

56.0 (6.4) a

Dark

77.1 (2.9)

19.7 (2.5)

2.2 (0.4)

22.5 (4.4)

16.4 (2.7)

72.0 (4.0)

23.5 (3.3)

3.2 (0.6)

26.5 (4.2)

19.8 (4.0)

24-h

54.5 (1.6)

37.2 (1.9)

6.3 (0.3)

101.5 (7.3)

100.5 (8.2)

56.8 (3.1)

35.7 (2.5)

5.6 (0.4)

86.8 (6.9) °

75.8 (7.8) °

SLEEP DEPRIVATION

98.8 (0.6)

1.2 (0.5)

0.0

1.0 (0.6)

0.0

99.8 (0.1)a

0.1 (0.1)a

0.0

0.0

0.0

RECOVERY Light

27.8 (4.5)

58.4 (4.0)

10.9 (0.6)

33.8 (1.6)

39.3 (2.0)

25.3 (2.5)

61.5 (2.1)

10.6 (0.4)

32.0 (2.0)

31.7 (2.3) °

Dark

73.8 (2.3)

21.7 (1.9)

3.3 (0.4)

24.1 (4.1)

21.4 (4.2)

62.0 (4.7) a

31.1 (3.9) °

5.2 (0.7)a

41.2 (4.7) a

34.8 (4.6)

  1. Mean values (SEM in parenthesis, Gria1+/+: n=8, Gria1-/-: n=6) of waking, NREM sleep (NREMS) and REM sleep (REMS) expressed as percentage of recording time, and the total number of NREMS and REMS episodes, shown for the 12-h light and dark period of baseline day, 6-h sleep deprivation (SD) and 18-h recovery. SD began at light onset. Differences between genotypes: ° p<0.1, a p<0.05, Wilcoxon rank sum test
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