Fig. 4: PSD95/nNOS binding inhibitor ZL006 prevents HFS-induced LTP of BLA neurons. | Translational Psychiatry

Fig. 4: PSD95/nNOS binding inhibitor ZL006 prevents HFS-induced LTP of BLA neurons.

From: PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD

Fig. 4

a Representative traces from individual experiments before and 1 h after HFS b LTP produced in the ZL006 treated cells following HFS was significantly depressed compared with vehicle and ZL007 conditions (Treatment: F2, 1243 = 434.0, P < 0.0001). Multiple comparisons post hoc analysis revealed that EPSP responses in cells treated with ZL006 were different from cells treated with vehicle or ZL007 at all time point t > 16 minutes (P < 0.05) (n = 10, 6 and 6 for vehicle, ZL007 and ZL006, respectively). c Membrane resistance was not different when compared between groups or over time (n = 8, 6, and 5 for vehicle, ZL007 and ZL006, respectively). Arrow indicates initiation of high frequency stimulation (HFS)

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