Fig. 5: Intra-amygdala infusion of ZL006 impairs memory formation of auditory fear conditioning. | Translational Psychiatry

Fig. 5: Intra-amygdala infusion of ZL006 impairs memory formation of auditory fear conditioning.

From: PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD

Fig. 5

a Schematic of the behavioral protocol. Rats were given intra-BLA infusion of ACSF (n = 10) or 10 µM ZL006 (n = 9) immediately after fear conditioning and the retention of conditioned fear memory was tested 24 h later. b Both pre-assigned vehicle and ZL006 groups of animals showed normal cued fear acquisition (Trial: F2, 34 = 308.8, P < 0.0001). c Animals treated with ZL006 showed significantly reduced freezing responses in the fear expression test (Treatment: F1, 17 = 4.974, P < 0.05). *P < 0.05 relative to vehicle

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