Table 1 Gene set enrichment among genes showing differential DA response, differentially expressed in baseline or in DA-stimulated LCLs between SZ cases and controls (FDR < 5%)
From: Transcriptomic signatures of schizophrenia revealed by dopamine perturbation in an ex vivo model
Analysis | Gene group | Total | Adult brain | % (p-value) | PGC2 GWS | % (p-value) | SZ-CNV | % (p-value) | Stanley_DEG | % (p-value) |
|---|---|---|---|---|---|---|---|---|---|---|
All genes | 21,043 | 10,829 | 51.46% | 297 | 1.41% | 145 | 0.69% | 407 | 1.93% | |
Regressing out known coavariates | Differential baseline expr | 6581 | 4508 | 68.50% (3.7E-133) | 113 | 1.72% (0.080) | 36 | 0.55% (0.255) | 174 | 2.64% (6.7E-04) |
Differential expr with DA | 4507 | 3065 | 68.01% (2.4E-60) | 75 | 1.66% (0.042) | 23 | 0.51% (0.222) | 122 | 2.71% (3.7E-05) | |
Differential DA response | 1455 | 1145 | 78.69% (3.2E-96) | 25 | 1.72% (0.360) | 14 | 0.96% (0.254) | 50 | 3.44% (3.3E-04) | |
Regressing out known coavariates + top 5 PCs | Differential baseline expr | 561 | 316 | 56.33% (0.023) | 11 | 1.96% (0.275) | 2 | 0.36% (0.596) | 15 | 2.67% (0.210) |
Differential expr with DA | 542 | 301 | 55.54% (0.061) | 8 | 1.48% (0.853) | 3 | 0.55% (0.241) | 7 | 1.29% (0.340) | |
Differential DA response | 588 | 461 | 78.40% (2.4E-40) | 15 | 2.55% (0.033) | 5 | 0.85% (0.608) | 23 | 3.91% (0.002) |
