Fig. 1 | Translational Psychiatry

Fig. 1

From: Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex

Fig. 1

Variability in peak location of craving. Locations of peak activity during a cue-induced craving task were isolated for the total sample (a) and independently for each drug-dependent group (b). Considered as a group (a), individuals had significantly more activity in the medial prefrontal cortex, and left (BA 44) and right (BA 8) lateral prefrontal cortices during drug–related pictures relative to neutral pictures. When each group was assessed independently (b) the location of peak activity was concentrated in the the medial prefrontal cortex/cingulate gyrus for the alcohol users (blue) and nicotine users (green). The cocaine users had significant clusters of activity in all three of the areas activated in the total group map (BA10, left BA 44, right BA8; red)

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