Fig. 3 | Translational Psychiatry

Fig. 3

From: Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex

Fig. 3

Cluster analysis of peak craving locations. a Silhouette plot of the optimal hotspot clustering solution. Spatial dispersion of the hotspots were characterized via k-means clustering (MATLAB, k + + algorithm cross-checked with R; 1000 repeats, random seeding, 1–10 clusters evaluated). K-means clustering for the full complement of hotspots revealed an optimal solution at 3 clusters (MNI Coordinates (x,y,z): 30, 18, 41; −40, 24, 25; 7, 50, 4). The cocaine, alcohol, and tobacco subgroups were evenly distributed through the clusters. b When considered as full complement, the EEG 10-10 coordinate FPz had the largest percentage of hotspots within a 2 cm (11%, red), 3 cm (19%, yellow), 4 cm (32%, green), and 5 cm (49%, blue) distance. This was also the best location for alcohol cues and smoking cues. The hotspots associated with cocaine cue-reactivity were closest to AF3, AF7, and AF5 (Red C)

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