Fig. 1: Association between methylation count in dopaminergic candidate markers and general IQ in n = 817 subjects.
From: Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?
a Plot of negative decadic logarithm of p-values for association of methylation count in CG site 50 kb pairs up- and downstream from dopaminergic candidate markers. Candidate markers were tyrosine hydroxylase (TH), DOPA decarboxylase (DDC), catechol-O-methyl transferase (COMT), dopamine transporter 1 (SLC6A3), dopamine receptor 1 (DRD1), and dopamine receptor 2 (DRD2). Among 24 identified CG sites we found significant associations of epigenetic candidate markers for dopamine D2 receptor (cg26132809) involved in dopamine neurotransmission with general IQ correcting for age, gender, study site, wave information, and variability in cell type. The red line marks p-value threshold for multiple comparison correction for each CG site (p < 2 × 10−3) and the dashed line for p < 0.05. b Correlation matrix of epigenetic candidate markers involved in dopaminergic neurotransmission. Only correlation indices are displayed at a significance level of p < 0.01 (i.e., R > 0.2). Correlation coefficients are color-coded (positive correlation blue, negative correlation red)
