Table 1 Non-human studies on acid-sensitive channels and panic-like symptoms
Study | Species | Strain | Sex | Weight | Acid channel | Control (n) | Panic (n) | Drugs | Area | F-value | p-value | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Almeida-Santos et al.24 | Rats | Wistar | Male | 220–240 g | TRPV1 | 9 | 7 | Capsazepine | dlPAG | F (8,33) = 2.81 | <0.05 | Blockade of TRVP1 receptors in the dlPAG decreases escape responses in animals exposed to the ETM test |
Batista et al.25 | Rats | Wistar | Male | 250–350 g | TRPV1 | 14 | 29 | Arachidonoyl-serotonin | IV route | F (3,39) = 1.07 | 0.37 | No effect of blockade on escape behavior |
Casarotto et al.26 | Rats | Wistar | Male | 300–330 g | TRPV1 | 9 | 20 | Capsazepine | dlPAG | F (3,25) = 16.58 | <0.05 | Capsazepine increases the threshold of electric current required to induce a panic-like response |
dos Anjos et al.27 | Rats | Wistar | Male | 230–270 g | TRPV1 | 8 | 8 | 6-I-CPS | Ventromedial hypothalamus | NA | >0.05 | Pretreatment with 6-I-CPS prevented escape behavior |
Lisboa et al.28 | Rats | Wistar | Male | 230–270 g | TRPV1 | 35 | 22 | Capsazepine | dlPAG | F (1,53) = 10.6 | <0.005 | Capsazepine reduced flight reactions |
