Fig. 4: Altered metabolic phenotypes persistent in the F2 and F3 generation of HFD fed dams. | Translational Psychiatry

Fig. 4: Altered metabolic phenotypes persistent in the F2 and F3 generation of HFD fed dams.

From: Transgenerational transmission of hedonic behaviors and metabolic phenotypes induced by maternal overnutrition

Fig. 4

a, b Body weight in the F2 and F3 generation respectively. The line plots depict the mean body weight per week for 11 consecutive weeks. N (F2 CTR) = 80 (48 m, 32 f); N (F2 HFD) = 86 (52 m, 34 f); N (F3 CTR) = 42 (22 m, 20 f); N (F3 HFD) = 52 (26 m, 26 f). c, d represent the distribution of fat in the F2 and F3 offspring, respectively. The bar plots show the average lean mass and percentage of fat mass ratio. N (F2) = 12 (6 m, 6 f) per group; N (F3) = 12 (6 m, 6 f) per group. e, f depict the insulin sensitivity in the F2 and F3 generation, respectively. The line plots show the blood glucose levels after 6 h fasting (time 0 min) and 15, 30, 60, 90, and 120 min following an insulin challenge injection. N (F2) = 16 (8 m, 8 f) per group; N (F3) = 16 (8 m, 8 f) per group. g, h show the metabolic profiles in the F2 and F3 offspring, respectively. The bar plots represent the concentrations of insulin and cholesterol. N (F2) = 12 (6 m, 6 f) per group; N (F3) = 12 (6 m, 6 f) per group. Data are represented as mean ± SEM. *p < 0.05, **p < 0.001, ***p < 0.0001. m, male; f, female

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