Table 1 Summary of the observed behavioral and metabolic phenotypes across three generations

	F0 dams (HFD exposed; 3 weeks preconception, 3 weeks gestation and 3 weeks lactation)	F1 offspring		F2 offspring		F3 offspring
		Male	Female	Male	Female	Male	Female
Hedonic response to drugs of abuse	NA	↑	↑	↑	↑	Ø	↑
Hedonic response to natural rewards	NA	↑	↑	Ø	Ø	Ø	Ø
Metabolic phenotypes	Ø	↑	↑	↑↑	↑↑	↑↑	Ø

In the table the summary of the observed behavioral and metabolic phenotypes of the F0 dams exposed to HFD and the subsequent F1, F2, and F3 offspring. Hedonic response to drugs of abuse referes to the alcohol preference test, amphetamine sensitivity test and the conditioned place preference response to cocaine. Hedonic response to natural rewards refers to the HFD and sucrose preference tests. Metabolic phenotypes comprise body weight (from weaning until adulthood), body fat assessment by CT-scan, insulin sensitivity and fasted plamsa insulin and lipid profiles. NA, not applicable; ɸ, no change; ↑↑, increased; ↑, mild increase only detected from late adulthood (PND 120)

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