Fig. 1: Principal component 4 (PC4) was associated with childhood abuse exposure (one sample per participant, N = 34).
From: Exposure to childhood abuse is associated with human sperm DNA methylation
PC4, representing 6.24% of the variance present in the methylation data, was significantly correlated (p < 0.05) with childhood abuse exposure. Darker regions signify stronger correlations between variables and principal components (N probes = 439,746). Normal sperm morphology is characterized, beginning at the head and moving toward the tail. Thus, “head morphology” is the % of sperm in a sample with normal heads, “neck morphology” is the % with normal heads and necks, and “tail morphology” is % with normal head, neck, and tail. Abstinence time is the time between the sperm donation and the most recent preceding ejaculation. PC principal component, CTQ Childhood Trauma Questionnaire, CTS Conflict Tactic Scale
