Fig. 2: Four genomic regions differentially methylated by childhood abuse.
From: Exposure to childhood abuse is associated with human sperm DNA methylation
Differentially methylated regions (DMRs) were defined as regions that differed statistically by abuse exposure at an FDR ≤ 0.05, had a mean Δβ ≥ 5% across probes, and were confirmed using replicates. The “CLU cluster” includes the 5’ UTR transcription start site and part of the gene body spanning 2.8 kb. The “MAPT cluster” is located in the gene body and spans 1.2 kb. The “SDK1 cluster” is located in the gene body and spans 1.5 kb. The “SYCE1 cluster” is located in the 5’ UTR and spans 200 bp
