Fig. 1

Six-month longitudinal changes in gFA: NAC vs placebo. Coronal, sagittal, and axial views (scalar gFA map) show voxel-wise analysis results indicating location (body of the fornix) of the group × time interaction, which reached significance (corrected p value < 0.04) (red cluster). Size of the cluster = 10 voxels. The graph shows extracted gFA values for each subject of each group (placebo, left; NAC, right) at baseline (T0) and follow-up (T1). Most placebo subjects show a decrease in gFA values, whereas NAC subjects show an increase