Table 1 Genes with detected variants across three affected individuals within family 3 (excluding microRNA and long intergenic non-protein-coding RNA)
From: Next-generation sequencing analysis of multiplex families with atypical psychosis
Gene | Cytogenic location | Polymorphisms | Ref | Alt | Function | Gene function |
|---|---|---|---|---|---|---|
PBX1 | 1q23.3 | rs117586882 | A | G | Intronic | Encodes a nuclear protein in the PBX homeobox family |
IL-7R | 5p13.2 | rs76614394 | C | T | 3′-UTR | A receptor for interleukin 7, cause of severe combined immunodeficiency |
NSMCE2 | 8q24.13 | rs200273856 | ACT | – | Intronic | Small ubiquitin-related modifier, nuclear transport, transcription, and DNA repair |
DCC | 18q21.2 | rs142009962 | C | T | Intronic | Netrin-1 receptor, axon guidance of neural cells |
DCC | 18q21.2 | rs143136177 | G | A | Intronic | |
DCC | 18q21.2 | rs149368621 | C | T | Intronic | |
DCC | 18q21.2 | rs148469099 | G | A | Intronic | |
ZFAS1 | 20q13.13 | rs199835143 | CTC | — | ncRNA_intronic | Unknown |
