Fig. 3: Neurofunctional activation patterns of fear-related brain structures in healthy controls during fear conditioning and extinction. | Translational Psychiatry

Fig. 3: Neurofunctional activation patterns of fear-related brain structures in healthy controls during fear conditioning and extinction.

From: A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety

Fig. 3

Healthy controls (n = 40) were subjected to an experimental fear conditioning and extinction task. Activation of brain regions was analyzed by means of fMRI as a function of minor (T)-alleles of rs2910931 (TT+AT: n = 25; AA: n = 15). Beta values from significant clusters were extracted and used for bar graph visualization (a.u.). a Activation of midbrain/periaqueductal gray, amygdala, and hippocampus regardless of conditioned stimulus presented during the second half of the extinction phase as a function of rs2910931 genotype group. b Interaction of rs2910931 genotype group with the conditioned stimulus presented during the first half of the extinction phase. *p < 0.05, **p < 0.01, and ***p < 0.001. CS+ conditioned stimulus that was followed by the unconditioned stimulus (US); CS− conditioned stimulus that was never followed by the US

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