Table 2 Genetic imaging analysis of rs2910931

From: A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety

Contrast/region

Side

Voxels

x

y

z

F or t

p a

Main group effects

       

 Acquisition first phase

     

No differential activation

 

 Acquisition second phase

       

 Inferior occipital lobe

L

156

−12

−96

−10

17.12

<0.001

 Post hoc t tests

 Acquisition second phase: risk>no risk

     

No differential activation

 

 Acquisition second phase: no risk>risk

 Inferior occipital lobe

L

225

−12

−96

−10

4.14

<0.001

 Extinction first phase

     

No differential activation

 

 Extinction second phase

 Midbrain (incl. right hippocampus)

 

550

0

−24

−16

16.85

<0.001

 Inferior parietal lobe

L

159

−54

−42

54

9.62

0.002

 Hippocampus (2 mm dev.)

L

355

30

−4

−18

12.33

0.001

 Amygdalab

L

16

−30

−2

−20

12.04

0.013

 Post hoc t tests

 Extinction second phase: risk>no risk

 Midbrain (incl. right hippocampus)

 

1018

0

−24

−16

4.11

<0.001

 Inferior parietal lobe

L

272

−54

−42

54

3.10

0.001

 Hippocampus (2 mm dev.)

L

737

30

−4

−18

3.51

<0.001

 Amygdalab

L

36

−30

−2

−20

3.47

0.007

 Lingual gyrus

L

196

−4

−78

−4

3.15

0.001

 Extinction second phase: no risk>risk

     

No differential activation

 

Group × CS interaction effects

 Acquisition first phase

 Inferior frontal gyrus pars triangularis

L

235

−44

28

26

13.11

<0.001

 Post hoc t tests

       

 Acquisition first phase: risk>no risk (CS + unpaired > CS−)

     

No differential activation

 

 Acquisition first phase: no risk>risk (CS + unpaired > CS−)

 Inferior frontal gyrus pars triangularis

L

429

−44

28

26

3.62

<0.001

 Acquisition second phase

 Caudate nucleus

L

378

−8

14

12

13.17

<0.001

 Middle temporal gyrus (4.47 mm dev.)

R

192

36

−60

4

12.50

<0.001

 Post hoc t tests

 Acquisition second phase: risk>no risk (CS + unpaired > CS−)

 Caudate nucleus

L

564

−8

14

12

4.31

<0.001

 Middle temporal gyrus (4.47 mm dev.)

R

348

36

−60

4

3.55

<0.001

 Acquisition second phase: no risk > risk (CS + unpaired > CS−)

     

No differential activation

 

 Extinction first phase

 Supplementary motor area

L

735

−2

22

60

22.76

<0.001

 Caudate nucleus (4.90 mm dev.)

R

219

20

12

28

12.92

<0.001

 Middle frontal gyrus (3.46 mm dev.)

L

218

−26

16

32

12.65

<0.001

 Post hoc t tests

 Extinction first phase: risk>no risk (CS +> CS−)

 Supplementary motor area

L

1599

−2

22

60

4.77

<0.001

 Middle cingulate gyrus

L

543

−4

−14

42

3.30

0.001

 Caudate nucleus (4.90 mm dev.)

R

432

20

12

28

3.59

<0.001

 Extinction first phase: no-risk > risk (CS +> CS−)

No differential activation

 Extinction second phase

No differential activation

  1. Main genotype effect of rs2910931 and genotype × CS interaction effects on brain activation patterns during fear acquisition and extinction are given as cluster peak voxels. Risk group status was defined as carrying at least one minor (T)-allele. During the acquisition, only CS+ trials that were not paired with the US were used for analyses
  2. L left, R right, voxel number of voxels per cluster, x, y, z MNI coordinates, dev deviation (in mm) from the identified anatomical structure using anatomic automatic labeling (aal). CS+ conditioned stimulus followed by the unconditioned stimulus (US) in 50% of trials during acquisition, CS− conditioned stimulus never followed by the US
  3. aUncorrected p values of whole-brain results with a minimum cluster size of 142 contiguous voxels are given, indicating p < 0.05 upon correction for multiple comparisons
  4. bSmall volume correction using aal masks (FWE correction at p < 0.05) with a cluster forming threshold of p < 0.001 was applied
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