Table 3 Major haplotypes (frequency > 0.05) within HTR3B and HTR3A associated with FTND in Chinese Han smokers

From: Association and cis-mQTL analysis of variants in serotonergic genes associated with nicotine dependence in Chinese Han smokers

Gene

SNP combination

Haplotype

Hap-Freq

Hap-Score

p-Hap

p-Global

HTR3B

rs3758987-rs4938056-rs1176744-rs2276305

T-T-A-G

0.14

3.67

0.00025

0.00547

C-T-C-G

0.14

−1.571

0.11535

 

T-T-A-A

0.26

−0.94

0.34542

 

T-C-A-G

0.40

−0.38

0.70192

 

HTR3A

rs1062613-rs1985242-rs2276302

T-A-G

0.09

1.28

0.20068

0.52552

C-A-A

0.18

−0.08

0.93544

 

C-T-A

0.71

−0.94

0.34864

 

rs10160548-rs1150220-rs1176713

G-A-G

0.10

1.35

0.17649

0.46057

G-G-A

0.10

−1.28

0.1997

 

G-G-G

0.14

−0.16

0.87608

 

T-G-A

0.66

0.04

0.97098

 
  1. The results were adjusted for age, working time, and area under additive model. Significant association is shown in boldface type. The corrected p value after Bonferroni correction for four tested major haplotypes in HTR3B is 0.0125 (0.05/4)
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