Table 4 Contrast analysis for pain i.e., Noxious Heat (PTSD: 46 °C–PTSD: 42 °C)–Control: 46 °C–Control: 42 °C)

From: Reward and aversion processing in patients with post-traumatic stress disorder: functional neuroimaging with visual and thermal stimuli

Brain region	Lat.	Zstat	x	y	z	cm³
Positive
Cortical
Frontal
Middle	R	4.5149	4	52	−12	6.216
Superior	L	3.3138	−14	50	34	2.912
Middle_Orbital	R	4.1583	28	48	22	5.256
Inferior_Triangular	R	3.088	50	46	−2	4.576
Superior_Medial	L	4.4573	−10	44	44	5.184
Middle	R	3.6398	6	44	−2	2.672
Inferior_Orbital	L	4.2308	−50	44	−8	6.816
Superior_Medial	L	3.2365	−8	42	24	1.888
Middle_Orbital	L	3.6153	−6	42	−14	0.88
Inferior_Orbital	L	3.3324	−34	38	−18	9.248
Rectus	L	3.8512	2	36	−24	4.568
Middle	L	3.0899	−30	34	42	2.344
Superior_Medial	L	3.6588	−6	32	40	2.976
Middle_Orbital	R	3.1365	40	32	22	11.888
Inferior_Triangular	L	3.2889	−50	32	14	3.848
Inferior_Orbital	R	3.6127	28	30	−24	2.392
Superior_Orbital	R	3.8527	14	28	52	3.488
Middle	L	3.1438	−50	20	40	2.84
Supp_Motor_Area	L	4.8875	−2	18	50	32.792
Precentral	L	3.1636	−46	2	40	9.48
Precentral	L	3.6611	−38	−16	58	9.592
Precentral	R	3.2171	32	−20	58	4.032
Parietal
Angular	R	3.1444	48	−50	30	4.584
Inferior	L	3.7698	−54	−56	36	4.592
Angular	R	3.4722	46	−60	30	2.368
Angular	R	3.3966	44	−62	26	2.136
Angular	L	3.9151	−52	−62	26	3.192
Occipital
Rolandic_Operculum	L	3.1518	−54	10	0	5.248
Temporal
Middle	L	3.0839	−50	4	−22	1.664
Middle	L	4.1141	−42	2	−30	6.616
Inferior	L	3.1285	−38	−24	−30	10.24
Inferior	R	3.8777	48	−48	−8	6.768
Middle	L	3.4588	−44	−52	16	6.072
Inferior	R	3.2829	54	−52	−8	1.856
Middle	L	3.5635	−56	−60	−4	8.112
Inferior	R	3.7377	58	−60	−18	6.792
Cingulum
Anterior	L	3.648	−6	42	8	6.88
Anterior	L	3.2944	−6	30	24	1.432
Anterior	L	4.1817	−6	22	22	5.728
Post	L	3.6965	−6	−48	28	8.08
Insula
Insula_Anterior	R	3.1325	30	22	−16	1.992
Insula_Anterior	R	3.1263	36	4	16	3.96
Sub-Cortical
Putamen	R	3.5437	26	14	0	4.256
Caudate	L	3.2604	−12	14	0	0.712
NAc	L	3.9158	−10	8	−6	4.928
Pallidum	L	3.4741	−14	2	−2	2.168
Amygdala	R	3.7746	32	−6	−12	5.96
Pallidum	R	3.9179	28	−14	−2	5.952
Hippocampus	L	3.7027	−22	−16	−16	7.408
Brainstem/Cerebellum
PAG		3.179	−2	−26	−6	3.456
Cerebellum_8	L	3.1324	−22	−38	−50	1.432
Cerebellum_6	R	6.2048	36	−46	−26	21.496
Cerebellum_Crus2	L	3.5623	−42	−56	−42	5.088
Cerebellum_8	R	3.6938	34	−56	−54	7.368
Vermis_4_5		3.1742	0	−60	−10	7.072
Cerebellum_6	R	3.3647	14	−60	−20	2.216
Cerebellum_Crus1	L	4.0219	−32	−62	−34	2.904
Cerebellum_Crus1	L	4.0019	−36	−62	−34	1.92
Cerebellum_6	L	3.717	−36	−62	−24	3.816
Cerebellum_Crus1	R	3.7558	52	−64	−32	2.8
Negative
Cortical
Frontal
Inferior_Orbital	L	2.1532	−30	34	−6	1.416
Rectus	L	2.9197	−6	26	−18	1.32
Middle_Orbital	R	2.0634	30	18	40	1.104
Precentral	L	1.9161	−36	0	30	0.336
Paracentral_Lobule	R	2.2028	8	−30	64	0.824
Parietal
Postcentral	L	2.1779	−58	−10	40	0.816
Postcentral	R	2.4261	48	−18	40	1.344
Postcentral	R	2.7418	34	−30	40	1.192
Fusiform	R	2.0777	24	−30	−20	1.504
Postcentral	R	2.9956	22	−36	80	2.152
Postcentral	L	2.0547	−26	−40	78	1.624
Precuneus	L	2.0737	−16	−42	68	1.024
Precuneus	L	2.1096	−8	−44	78	0.424
Precuneus	R	2.3315	26	−50	2	0.968
Superior	R	2.0322	22	−50	70	0.424
Inferior	L	1.8085	−32	−52	48	0.256
Occipital
Middle	L	2.1494	−28	−60	32	1.432
Temporal
Superior	R	2.0631	62	2	−2	0.664
Superior	R	1.9796	66	−14	10	0.424
Superior	L	1.9296	−66	−26	6	0.456
Superior	R	2.3064	44	−42	4	1.152
Superior	R	1.856	62	−44	20	0.448
Lingual	R	2.0713	16	−46	−6	0.752
Middle	R	2.6184	64	−52	10	1.92
Cingulum
Middle	R	2.8207	14	10	42	3.448
Middle	R	2.7638	12	−20	46	1.92
Insula
Insula_Posterior	L	2.2091	−46	−10	4	0.616
Sub-Cortical
Amygdala	L	2.2135	−24	−2	−22	0.48
Hypothalamus	R	2.2421	4	−4	−14	0.616
Brainstem/Cerebellum
Cerebellum_Crus2	L	2.742	−52	−44	−42	1.112
Cerebellum_4_5	L	1.788	−8	−44	−4	0.232
Cerebellum_9	L	1.7861	−12	−52	−42	0.216

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Table 4 Contrast analysis for pain i.e., Noxious Heat (PTSD: 46 °C–PTSD: 42 °C)–Control: 46 °C–Control: 42 °C)

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