Fig. 2: Performance of Df(h22q11)/ + and wild-type littermates on the 2-stimulus training stage 3 and the baseline 5-stimulus rCPT. | Translational Psychiatry

Fig. 2: Performance of Df(h22q11)/ + and wild-type littermates on the 2-stimulus training stage 3 and the baseline 5-stimulus rCPT.

From: Continuous performance test impairment in a 22q11.2 microdeletion mouse model: improvement by amphetamine

Fig. 2

Performance of Df(h22q11)/ + and wild-type littermates on the 2-stimulus training stage 3 and the baseline 5-stimulus rCPT). Data are presented as means ± SEM. Discrimination sensitivity (d’) is an index of the subject’s ability to distinguish target from non-target stimuli, while response criterion (c) describes the subject’s propensity to respond to any stimulus. a 2-stimulus: d’ and c. Df(h22q11)/+ mice had increased response criterion c. Df(h22q11)/+ mice showed a non-significant decrease in d’ (p = 0.051) relative to littermate controls. b 2-stimulus: hit rate and false alarm rate. Df(h22q11)/+ mice had decreased hit rates relative to controls. There was no effect of genotype on false alarm rate. c 5-stimulus rCPT: d’ and c. Df(h22q11)/+ mice had decreased d’ relative to controls. There was no effect of genotype on response criterion. d 5-stimulus rCPT: hit rate and false alarm rate. Df(h22q11)/+ mice showed decreased hit rate relative to controls. There was no effect of genotype on false alarm rate. Asterisk denotes significant effect of genotype (*p < 0.05)

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