Fig. 4: Performance of Df(h22q11)/ + and wild-type littermates on the 5-stimulus rCPT when treated with acute systemic modafinil and amphetamine.

Performance of Df(h22q11)/ + and wild-type littermates on the 5-stimulus rCPT when treated with acute systemic modafinil and amphetamine). Data are presented as means ± SEM. Discrimination sensitivity (d’) is an index of the subject’s ability to distinguish target from non-target stimuli, while response criterion (c) describes the subject’s propensity to respond to any stimulus. a Modafinil: d’ and c. Modafinil caused a dose-linear decrease in d’ in the Df(h22q11)/+ model. There was no effect of modafinil on response criterion c. b Modafinil: hit rate and false alarm rate. Modafinil had no significant effects on hit rate or false alarm rate. c Amphetamine: d’ and c. Amphetamine caused a dose-linear increase in d’ in the Df(h22q11)/+ model. 1.0 mg/kg amphetamine tended to increase c in control animals only. d Amphetamine: hit rate and false alarm rate. Amphetamine reduced hit rate in control animals only at the 1.0 mg/kg dose. Amphetamine caused a genotype-independent reduction in hit rate at the 1.0 mg/kg dose. Pink shading denotes significant dose-linear effect that were selective to the Df(h22q11)/+ model (Ψ = p < 0.05). Asterisk denotes significant main effect of genotype (* = p < 0.05). Gray shading and hash denote significant genotype-independent dose differences (# = p < 0.05). Grey shading and lambda denote significant dose differences in Df(h22q11)/+ model (λ = p < 0.05). ‘V’ denotes drug vehicle condition (modafinil: saline + 0.5% arabic gum, amphetamine: saline)