Fig. 4: Cell type and neurodevelopmental disorder genetic risk loci enrichment.

a Cell type enrichment analysis for the identified transcriptome- and proteome-based modules. The number of significantly overlapping HGNC symbols are displayed (**p < 0.0001; *0.01 > p < 0.05). b Genetic risk loci enrichment analysis according to transcriptome- and proteome-based modules. Five previously generated lists of neurodevelopmental disorder risk loci were used, including intellectual disability (ID), developmental delay (DD), autism spectrum disorder (ASD), epilepsy, and schizophrenia (SCZ). Data information: In a, three cell type marker resources were leveraged, including two based on transcriptome profiling^36,37 and one based on proteome profiling³⁸