Table 1 Top ten down and up age-related proteins throughout postnatal development with paired RNA products

From: Temporal proteomic profiling of postnatal human cortical development

Uniprot ID

HUGO gene symbol (name)

Proteome

Transcriptome

  

t-statistic

Adj. p-value

t-statistic

Adj. p-value

O15075

DCLK1 (doublecortin like kinase 1)

−10.786

6.02E−16

−3.836

4.46E−04

P22676

CALB2 (calbindin 2)

−9.154

3.51E−13

−11.731

2.31E−14

Q9BPU6

DPYSL5 (dihydropyrimidinase like 5)

−8.951

7.86E−13

−12.522

3.05E−15

P52306

RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1)

−8.950

7.90E−13

−5.331

4.39E−06

P05413

FABP3 (fatty acid binding protein 3)

−8.511

4.57E−12

−2.295

2.72E−02

P29966

MARCKS (myristoylated alanine rich protein kinase C substrate)

−8.321

9.79E−12

−11.097

1.24E−13

Q12860

CNTN1 (contactin 1)

−7.733

1.05E−10

−3.490

1.22E−03

P55072

VCP (valosin containing protein)*

−7.688

1.25E−10

−3.995

2.78E−04

Q6PCE3

PGM2L1 (phosphoglucomutase 2 like 1)

−7.639

1.53E−10

−7.150

1.33E−08

O14594

NCAN (neurocan)

−7.256

7.13E−10

−8.759

9.49E−11

P09417

QDPR (quinoid dihydropteridine reductase)

7.707

1.16E−10

10.303

1.09E−12

P49189

ALDH9A1 (aldehyde dehydrogenase 9 family member A1)

6.201

4.81E−08

2.478

1.77E−02

O94856

NFASC (neurofascin)

5.917

1.47E−07

3.699

6.65E−04

P07602

PSAP (prosaposin)†, ‡

5.818

2.16E−07

9.804

4.47E−12

P12277

CKB (creatine kinase B)

5.590

5.22E−07

N/A

N/A

O94811

TPPP (tubulin polymerization promoting protein)

5.257

1.86E−06

10.842

2.47E−13

P14618

PKM (pyruvate kinase, muscle)

5.190

2.39E−06

10.344

9.73E−13

Q16653

MOG (myelin oligodendrocyte glycoprotein)

5.180

2.48E−06

4.991

1.29E−05

P13611

VCAN (versican)

5.170

2.58E−06

−2.601

1.31E−02

Q969P0

IGSF8 (immunoglobulin superfamily member 8)

5.038

4.21E−06

2.104

4.19E−02

  1. N/A not detected
  2. Linear regression models adjusted for pH, PMI, sex, and ethnicity. The direction of change (t-statistic) across postnatal development and p-value significance are displayed for each protein and paired RNA product. Candidate neurodevelopmental genetic risk loci are symbolized: *, autism; †, intellectual disability; ‡, schizophrenia