Table 3 Transporter, 5-HT1A and 5-HT2A binding in suicide and major depressive disorder

From: Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity

All cases were sudden-death cases.

Receptor

n

Group

BA 8

BA 9

BA 46

BA 45

BA 47

BA 11

BA 12

BA 32

BA 24

SERT

143

NonSuicide

5.86 ± 2.13

6.38 ± 2.6

6.83 ± 2.84

8.81 ± 4.42

9.62 ± 5.22

10.13 ± 5.55

11.21 ± 5.36

9.9 ± 4.29

23.91 ± 11.98

 

77

Suicide

5.35 ± 2.61

5.76 ± 2.96

5.81 ± 3.46*

7.65 ± 4.31

8.8 ± 5.43

9.52 ± 6.15*

9.34 ± 5.5*

9.05 ± 6.53

20.49 ± 16.63

5-HT1A

143

NonSuicide

13.93 ± 4.77

14.66 ± 4.99

14.24 ± 4.79

14.75 ± 4.64

17.72 ± 5.57

19.18 ± 6.54

18.42 ± 6.2

16.15 ± 5.55

19.45 ± 7.18

 

79

Suicide

14.19 ± 4.03

14.59 ± 4.64

14.97 ± 4.61*

15.19 ± 3.86

18.07 ± 4.87

19.68 ± 5.97

18.62 ± 5.43

16.26 ± 3.97

18.49 ± 6.08

5-HT2A

145

NonSuicide

29.38 ± 10.82

29.58 ± 10.82

29.36 ± 9.96

30.36 ± 10.55

32.76 ± 11.35

33.13 ± 11.55

33.22 ± 11.52

30.03 ± 10.05

25.48 ± 9.57

 

78

Suicide

30.05 ± 12.09

30.34 ± 12.54

31.41 ± 12.59

30.24 ± 11.48

33.65 ± 12.52

33.43 ± 12.55

32.93 ± 12.5

30 ± 11.69

23.21 ± 9.05

Only cases with psychological autopsy:

Receptor

n

Group

BA 8

BA 9

BA 46

BA 45

BA 47

BA 11

BA 12

BA 32

BA 24

SERT

102

NonSuicide

5.7 ± 2.1

6.3 ± 2.58

6.73 ± 2.73

8.46 ± 4.53

9 ± 5.06

9.55 ± 4.79

10.92 ± 4.95

9.58 ± 4.17

22.54 ± 11.58

 

55

Suicide

4.58 ± 2.19

5.33 ± 2.64

5.4 ± 3.07

6.8 ± 3.64

8.11 ± 5.42

8.9 ± 6.5

8.15 ± 4.76

7.61 ± 4.55

15.63 ± 12.95

5-HT1A

100

NonSuicide

12.79 ± 3.76

14.01 ± 4.34

13.28 ± 3.84

14.06 ± 4.28

16.51 ± 5.32

17.98 ± 5.85

17.42 ± 5.95

14.81 ± 5.04

18.14 ± 6.43

 

56

Suicide

14.68 ± 4.06*

14.88 ± 4.4

15.53 ± 4.34*

15.26 ± 3.55

18.27 ± 4.85*

20.06 ± 5.8*

18.8 ± 4.86

16.09 ± 4.16

19.67 ± 5.96

5-HT2A

104

NonSuicide

27.37 ± 9.08

28.42 ± 10.37

29.14 ± 9.88

29.65 ± 10.12

32.1 ± 10.57

32.99 ± 11.3

32.96 ± 11.22

29.35 ± 9.34

24.6 ± 8.74

 

56

Suicide

31.09 ± 13.85*

31.67 ± 13.68*

32.82 ± 13.26*

31.76 ± 12.19

35.41 ± 13.15*

35.43 ± 13.03

34.31 ± 13.42

31.07 ± 12.92

23.43 ± 9.82

SERT

112

NoMDD

5.65 ± 2.11

6.33 ± 2.62

6.65 ± 2.71

8.41 ± 4.49

9.11 ± 5.27

9.77 ± 5.24

10.85 ± 4.97

9.63 ± 4.21

21.83 ± 12.17

 

47

MDD

4.55 ± 2.17

5.1 ± 2.45*

5.28 ± 3.14*

6.6 ± 3.44*

7.68 ± 4.81

8.2 ± 5.71

7.72 ± 4.52*

7.04 ± 4.27*

16.28 ± 11.94

5-HT1A

110

NoMDD

13 ± 3.63

14.14 ± 4.22

13.68 ± 3.93

14.31 ± 4.09

16.92 ± 5.03

18.54 ± 5.6

17.67 ± 5.81

15.04 ± 4.79

18.19 ± 6.07

 

48

MDD

14.72 ± 4.49*

14.94 ± 4.7

15.15 ± 4.47*

14.99 ± 3.93

17.71 ± 5.48

19.16 ± 6.52

18.61 ± 4.99

15.96 ± 4.67

19.77 ± 6.77*

5-HT2A

112

NoMDD

28.03 ± 10.31

29.02 ± 11.12

29.7 ± 10.63

29.97 ± 10.4

32.79 ± 11.24

33.53 ± 11.67

33.28 ± 11.84

29.63 ± 9.83

24.91 ± 9.03

 

50

MDD

29.72 ± 12.27

30.8 ± 12.85

32.22 ± 12.57

31.35 ± 11.78

34.18 ± 12.23

34.19 ± 12.66

33.55 ± 12.34

30.61 ± 12.31

21.6 ± 8.39

  1. Values are expressed as fmol/mg tissue, mean ± SD
  2. *p < 0.05
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