Table 4 Transporter, 5-HT1A and 5-HT2A binding in suicide and major depressive disorder in subjects with and without alcohol use disorder

From: Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity

Only alcoholic cases:

Receptor

n

Group

BA 8

BA 9

BA 46

BA 45

BA 47

BA 11

BA 12

BA 32

BA 24

SERT

52

NonSuicide

5.56 ± 2.01

6.48 ± 2.59

7.02 ± 2.95

9.14 ± 5.55

9.51 ± 6.36

10.24 ± 5.87

11.56 ± 4.48

10.1 ± 3.89

24.32 ± 8.93

 

20

Suicide

5.54 ± 2.57

6.27 ± 2.75

6.36 ± 2.57

8.29 ± 4.06

10.2 ± 6.65

11.42 ± 8.29

9.3 ± 4.99

9.46 ± 5.37

21.81 ± 16.08

5-HT1A

49

NonSuicide

13.04 ± 4.43

14.6 ± 4.65

13.65 ± 3.79

14.59 ± 4.39

17.07 ± 5.51

18.9 ± 5.97

17.19 ± 5.37

15.29 ± 5.41

18.81 ± 7.44

 

20

Suicide

15.96 ± 3.38

16.15 ± 3.89

16.31 ± 3.34

15.6 ± 2.8

19.72 ± 4.46

22.18 ± 6.24

18.77 ± 4.96

17.53 ± 3.85

22.24 ± 4.73

5-HT2A

52

NonSuicide

26.31 ± 10.13

28.46 ± 11.36

29.77 ± 9.91

28.65 ± 9.76

32.01 ± 10.6

33.14 ± 10.84

33.43 ± 10.21

28.74 ± 9.93

21.84 ± 8.28

 

19

Suicide

38.94 ± 12.19

36.59 ± 12.73

38.32 ± 12.07

35.53 ± 10.59

39.52 ± 11.59

38.9 ± 10.53

38.84 ± 12

34.99 ± 11.33

30.2 ± 10.99

SERT

57

NoMDD

5.62 ± 2.08

6.49 ± 2.65

6.99 ± 2.88

9.18 ± 5.41

9.83 ± 6.59

10.75 ± 6.49

11.52 ± 4.73

10.39 ± 3.92

23.97 ± 10.57

 

14

MDD

5.35 ± 2.66

6.13 ± 2.68

6.12 ± 2.87

7.44 ± 3.88

9.12 ± 6.09

9.85 ± 7.55

8.13 ± 3.97

7.97 ± 5.54

19.91 ± 12.92

5-HT1A

55

NoMDD

13.33 ± 4.16

14.7 ± 4.43

14.15 ± 3.91

14.74 ± 4.17

17.42 ± 4.96

19.47 ± 5.63

17.41 ± 5.22

15.42 ± 4.98

18.97 ± 6.78

 

13

MDD

16.66 ± 4.52

16.53 ± 4.72

15.57 ± 3.61

15.65 ± 3.3

19.67 ± 6.71

21.51 ± 8.49

18.83 ± 5.74

18.24 ± 5.22

24.03 ± 6.03

5-HT2A

56

NoMDD

27.93 ± 12.35

29.78 ± 12.48

31.22 ± 11.23

29.54 ± 10.53

33.49 ± 11.81

34.32 ± 11.57

34.56 ± 11.52

29.74 ± 10.81

23.05 ± 9.42

 

14

MDD

36.21 ± 9.18

33.82 ± 11.3

35.97 ± 11.11

34.53 ± 9.52

36.68 ± 9.77

36.66 ± 8.93

36.97 ± 8.89

32.3 ± 10.01

26.92 ± 9.42

Only non-alcoholic cases

Receptor

n

Group

BA 8

BA 9

BA 46

BA 45

BA 47

BA 11

BA 12

BA 32

BA 24

SERT

50

NonSuicide

5.82 ± 2.19

6.11 ± 2.59

6.45 ± 2.5

7.79 ± 3.17

8.49 ± 3.28

8.89 ± 3.38

10.41 ± 5.29

9.06 ± 4.42

21 ± 13.42

 

36

Suicide

4.07 ± 1.73

4.82 ± 2.42

4.97 ± 3.19

6.1 ± 3.2

6.9 ± 4.05

7.53 ± 4.67

7.66 ± 4.64

6.52 ± 3.51

12.83 ± 10.65

5-HT1A

51

NonSuicide

12.6 ± 3.16

13.44 ± 3.97

12.94 ± 3.9

13.57 ± 4.16

15.94 ± 5.11

17.11 ± 5.67

17.64 ± 6.48

14.37 ± 4.68

17.6 ± 5.59

 

37

Suicide

13.83 ± 4.22

14.19 ± 4.49

15.09 ± 4.72

15.03 ± 3.89

17.41 ± 4.85

18.84 ± 5.14

18.74 ± 4.82

15.27 ± 4.1

17.7 ± 5.98

5-HT2A

52

NonSuicide

28.25 ± 8.14

28.38 ± 9.39

28.61 ± 9.93

30.68 ± 10.47

32.2 ± 10.65

32.84 ± 11.83

32.55 ± 12.12

29.97 ± 8.76

26.72 ± 8.6

 

38

Suicide

26.92 ± 12.7

29.14 ± 13.43

30.39 ± 13

29.57 ± 12.48

32.96 ± 13.38

33.34 ± 13.83

31.88 ± 13.46

29.16 ± 13.21

18.85 ± 6.4

SERT

55

NoMDD

5.68 ± 2.17

6.16 ± 2.6

6.33 ± 2.53

7.64 ± 3.15

8.36 ± 3.31

8.81 ± 3.41

10.29 ± 5.15

8.86 ± 4.39

20.02 ± 13.28

 

31

MDD

4.04 ± 1.82

4.57 ± 2.26

4.93 ± 3.3

6.15 ± 3.32

6.97 ± 4.14

7.48 ± 4.8

7.48 ± 4.82

6.52 ± 3.54

13.49 ± 11.53

5-HT1A

55

NoMDD

12.71 ± 3.14

13.58 ± 3.97

13.22 ± 3.94

13.87 ± 4.01

16.37 ± 5.1

17.58 ± 5.46

17.91 ± 6.38

14.66 ± 4.6

17.53 ± 5.42

 

33

MDD

13.81 ± 4.48

14.05 ± 4.58

14.87 ± 4.91

14.69 ± 4.27

16.86 ± 4.96

18.21 ± 5.62

18.39 ± 4.91

14.86 ± 4.24

17.91 ± 6.43

5-HT2A

56

NoMDD

28.1 ± 8.47

28.26 ± 9.63

28.42 ± 10.03

30.41 ± 10.36

32.06 ± 10.68

32.76 ± 11.83

32.14 ± 12.13

29.51 ± 8.82

26.36 ± 8.56

 

34

MDD

27.03 ± 12.85

29.44 ± 13.54

30.93 ± 13.16

29.9 ± 12.92

33.27 ± 13.57

33.54 ± 14.02

32.52 ± 13.6

29.89 ± 13.53

17.7 ± 5.63

  1. Values are expressed as fmol/mg tissue, mean ± SD
  2. BA Brodmann area, MDD major depressive disorder, SERT serotonin transporter
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