Table 3 Genomic regions with p < 1×10−5 in the genome-wide association study (GWAS) on the dissociation effects to ketamine
CHR | SNP | BP | A1 | A2 | FRQ | INFO | BETA | SE | P | Gene (distance) | Protein (distance) |
|---|---|---|---|---|---|---|---|---|---|---|---|
5 | rs17211233 | 80368763 | T | C | 0.9389 | 0.9349 | −26.9757 | 4.7058 | 1.90E-07 | RASGRF2 (0) | RASGRF2 (0) |
3 | rs1400237 | 76172232 | T | G | 0.0778 | 1.0706 | 21.4345 | 4.165 | 2.02E-06 | ROBO2 (0) | ROBO2 (0) |
9 | rs12236015 | 122817820 | C | T | 0.833 | 1.1168 | −13.9838 | 2.7763 | 3.10E-06 | ||
3 | rs9713737 | 76297174 | A | G | 0.244 | 0.9868 | 13.5351 | 2.7481 | 4.79E-06 | ROBO2 (0) | ROBO2 (0) |
2 | rs77987715 | 65955079 | A | G | 0.6547 | 1.0199 | −11.7152 | 2.3832 | 4.97E-06 | SPRED2 (295308) | |
4 | rs3900502 | 189869233 | C | A | 0.4877 | 0.8444 | −12.2832 | 2.5129 | 5.53E-06 | TRIML1 (808660) | |
11 | rs3018154 | 94420308 | C | T | 0.9111 | 1.0392 | −19.9461 | 4.0971 | 5.97E-06 | AMOTL1 (19289) | |
20 | rs1287071 | 5828375 | A | G | 0.7111 | 1.1346 | −11.3492 | 2.3349 | 6.15E-06 | C20orf196 (0) | C20orf196 (0) |
2 | rs11127199 | 29213561 | G | A | 0.6335 | 0.995 | 11.445 | 2.3621 | 6.53E-06 | FAM179A (0) | FAM179A (0) |
3 | rs4855976 | 76267368 | A | G | 0.0702 | 0.7747 | 23.7477 | 4.9636 | 8.24E-06 | ROBO2 (0) | ROBO2 (0) |
20 | rs11907319 | 42923299 | T | C | 0.8099 | 0.9753 | 14.3351 | 3.0037 | 8.63E-06 | FITM2 (16510) | FITM2 (16510) |
15 | rs4558394 | 98322385 | A | G | 0.85 | 0.9108 | −15.6495 | 3.2958 | 9.46E-06 | LINC00923 (0) | LINC00923 (0) |
