Fig. 3: Relative proportion of PDE8A mRNA isoforms in two discrete brain regions of control (A) and suicide (B) subjects.
From: Brain region-specific alterations of RNA editing in PDE8A mRNA in suicide decedents
a Comparison of the relative isoform proportion of PDE8A in BA24 and BA9 within the control group. The PDE8A isoforms are depicted in order of significance and abundance in BA24. b Comparison of the relative isoform proportion of PDE8Ain BA24 and BA9 in the suicide group. In this representation, a negative percentage from the median indicates that the relative proportion of the isoform is higher in BA9 compared with BA24. Filled bars in (a) and (b) indicate the most significant differences of the isoform proportion between the two brain structures in both control and suicide groups. Criteria for the selection are (1) a p-value (FDR) ≤ 0.05 using the one-sample Wilcoxon signed rank test (where null hypothesis H0: median variation = 0) and (2) a median variation ≥ ± 20%. The symbol * indicates a p-value (FDR) ≤ 0.05, ** indicate a p-value (FDR) ≤ 0.01 and *** indicate a p-value (FDR) ≤ 0.001
