Fig. 2: Consequences of the regional-specific ablation of Pyk2 on the behavioral effects of CUMS.

a Pathlength traveled in an open field apparatus during a 30 min session. Two-way ANOVA, genotype effect: F_{(5, 74)} = 5.42, p = 0.0003. b Time in the center in an open field apparatus during 30 min. One-way ANOVA, genotype effect: F_{(5, 76)} = 2.349, p = 0.0488. c Forced swimming test: % of time struggling from the 3rd to the 6th minute in a 6-min long session. One-way ANOVA: F_{(5, 76)} = 20.83, p < 0.0001. d Forced swimming test: % of time struggling from the 1st to the 2nd minute in a 6-min long session. One-way ANOVA: F_{(5, 76)} = 45.34, p < 0.0001. e Elevated plus maze test, time spent in open arms, One-way ANOVA and Tukey’s post hoc test: F_{(5, 76)} = 4.396, p = 0.001. f Pathlength traveled in the elevated plus maze. One-way ANOVA and Tukey’s post hoc test: F_{(5, 76)} = 1.19, p = 0.32. g Sucrose preference test: Preference for sweet water over plain water (%). Three consecutive days of testing were evaluated in the sucrose preference test. One-way ANOVA: day 1, F_{(5, 79)} = 2.91, p = 0.018; day 2: F_{(5, 79)} = 7.34, p < 0.0001; day 3: F_{(5, 79)} = 3.86, p = 0.003. Post-hoc Tukey’s test. Data are means + SEM. a–g GFP group (n = 10); CUMS-GFP group (n = 13); CUMS-mPFC group (n = 15); CUMS-Nacc group (n = 15); CUMS-Hipp group (n = 15); CUMS-Amy group (n = 14). *p < 0.05 and **p < 0.01 compared to unstressed GFP group and ^$p < 0.05 compared to CUMS-GFP group