Fig. 4: Hormonal contraceptive (HC)-treated females with low estradiol levels have significantly elevated Ang II levels, but did not affect angiotensin II type I receptor (AT1R) binding.
From: Estradiol modulation of the renin–angiotensin system and the regulation of fear extinction
a Estradiol levels are significantly reduced in HC-treated females compared with proestrus vehicle-treated intact females (n = 7–12/group). b HC-treated females (low E2) have significantly elevated Ang II levels compared with vehicle-treated proestrus females (high E2). No significant differences in AT1R ligand binding were detected between HC- and vehicle-treated gonadally intact female rats in the c infralimbic cortex, d anterior piriform cortex, e basolateral amygdala (BLA), f paraventricular nucleus of the hypothalamus, g posterior piriform cortex, or h ventral subiculum. ***p < 0.001; *p < 0.05
