Fig. 1: The effect of sex and age on peripheral and central kynurenic acid (KYNA) levels in healthy controls (HCs) and bipolar disorder (BD) subjects.
From: Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls
a Plasma KYNA levels in female and male HCs. b Plasma KYNA levels in female and male bipolar subjects. c The effect of age on plasma KYNA levels in HCs. d The effect of age on plasma KYNA levels in bipolar subjects. e CSF KYNA levels in female and male HCs. f CSF KYNA levels in female and male bipolar subjects. g The effect of age on CSF KYNA levels in HCs. h The effect of age on CSF KYNA levels in bipolar subjects. Group comparisons in a, b, e, and f were performed using logistic regression models (age as covariate) with sex as dependent variable (0 = male, 1 = female). Correlation coefficients in c, d, g, and h are Spearman’s (rs) and derived from partial correlation analyses with sex as a covariate. All reported P-values are two-sided
