Fig. 2: Peripheral and central kynurenic acid (KYNA) levels in healthy controls (HCs) and bipolar disorder (BD) subjects.
From: Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls
a Plasma KYNA levels in HCs (median = 37.7 nM, IQR = 18.6) and BD I/II subjects (median = 37.0 nM, IQR = 23.2). b Cerebrospinal fluid (CSF) KYNA levels in HCs (median = 1.56 nM, IQR = 1.03) and BD I/II subjects (median = 1.66 nM, IQR = 1.16). c Correlations between plasma and CSF KYNA levels in HCs. d Correlations between plasma and CSF KYNA levels in BD I/II subjects. Group comparisons were performed using logistic regression models (age- and sex as covariates) with group as dependent variable (0 = HC, 1 = BD). Reported correlation coefficients (panel c and d) are Spearman’s (rs) and derived from partial correlation analyses with age and sex as covariates or partial correlation analyses with age as a covariate (stratified on sex). See also Fig. S1 and S2. All reported P-values are two-sided
