Table 2 Changes in cognitive performance after a 12-week MDCT intervention

From: Computerized multi-domain cognitive training reduces brain atrophy in patients with amnestic mild cognitive impairment

 

Baseline

3 months

P value

Overall cognition

MMSE

27.35 ± 2.23

27.06 ± 2.97

0.589

MoCA

22.47 ± 4.47

21.88 ± 4.29

0.347

Memory

HVLT-R immediate recall Trial 1

5.53 ± 1.74

4.94 ± 1.85

0.106

HVLT-R immediate recall Trial 2

7.18 ± 1.78

6.82 ± 1.55

0.463

HVLT-R immediate recall Trial 3

7.88 ± 1.80

8.00 ± 1.23

0.805

HVLT-R immediate recall total

20.59 ± 4.77

19.76 ± 3.62

0.456

HVLT-R delayed recall

5.12 ± 2.90

5.35 ± 2.93

0.753

HVLT-R retention (%)

59.94 ± 33.82

63.91 ± 34.06

0.656

HVLT-R recognition discrimination Index

8.12 ± 3.04

7.76 ± 3.58

0.231

Speed of processing

Trail Making Test Part A (s)

79.06 ± 48.57

76.18 ± 39.76

0.600

Visuospatial ability

BVMT-R immediate recall total score

18.35 ± 7.83

16.53 ± 8.74

0.286

BVMT-R delayed recall score

6.88 ± 3.50

6.88 ± 3.84

1.000

Language

Verbal Category Fluency

16.59 ± 4.05

16.65 ± 4.51

0.956

Attention and working memory

Digit Span total score

15.47 ± 4.35

16.24 ± 3.44

0.389

Space Span total score

13.41 ± 2.83

13.41 ± 3.94

1.000

Executive function

Stroop-word

65.94 ± 10.18

65.88 ± 10.02

0.968

Stroop-colour

51.75 ± 9.42

53.06 ± 7.59

0.402

Stroop- Color-Word

24.88 ± 7.44

24.75 ± 8.13

0.943

Golden’s Interference Score

−3.94 ± 7.08

−4.44 ± 7.67

0.764

Reasoning

Modified Picture Completion

7.41 ± 1.66

6.88 ± 1.76

0.058

  1. MMSE mini-mental state examination, MoCA montreal cognitive assessment, HVLT-R Hopkins verbal learning test–revised, BVMT-R Brief Visuospatial Memory Test–revised