Fig. 2: Boxplots of RANlet trait for lead variants.

Boxplots of the RANlet trait as a function of genotype of the lead variants rs17663182 (left side, major allele G) and rs16928927 (right side, major allele C). Genotype counts are G/G = 2,092; T/G = 307; T/T = 16; missing = 148 for rs17663182 and C/C = 1,965; T/C = 259; T/T = 7; missing =332 for rs16928927 (Note: missing counts include Finland, where rs16928927 was not available). To generate these plots, all datasets were pooled together. RANlet Z-scores plotted here are residualized against the first 10 MDS covariates in all datasets except for Colorado, where we adjusted the phenotypic measure for pairwise genetic relatedness in GenABEL113 (see Supplementary Methods section)