Fig. 2: Cortical and subcortical relationships between gene expression and association with schizophrenia and bipolar disorder.

Relationships between gene expression and psychiatric genetic association were determined from separate analyses of prefrontal cortex (a, b), non-prefrontal cortex (c, d) and subcortical regions (e, f). Prefrontal Cortex includes medial prefrontal cortex, dorsolateral prefrontal cortex, ventrolateral prefrontal cortex and orbital frontal cortex. Non-prefrontal cortex includes posterior superior temporal cortex, inferolateral temporal cortex, primary auditory cortex, primary visual cortex, primary motor cortex, posteroventral parietal cortex and primary somatosensory cortex. Subcortical regions include amygdaloid complex, thalamus, striatum and hippocampus. Bars represent −log₁₀(P) sgn(β), where P is uncorrected following gene property analysis and β is the corresponding regression coefficient. Dotted lines show significance thresholds accounting for multiple testing for 13 developmental stages and three subregion groups