Table 2 Association studies of HCRTR1 rs2271933 and CBT treatment response

From: Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes

   

Baseline

Post CBT

Effect size

CT vs CC Effect size difference

TT vs CC Effect size difference

TT vs CT Effect size difference

Outcome

Genotype

N

Mean

SD

Mean

SD

d

95%

CI

p-value

d

95%

CI

p-value

d

95%

CI

p-value

d

95%

CI

p-value

HAM-Aα

CC

58

25.2

5.5

12.1

6.9

−2.5

−2.9

−2.1

4.83·10−18

            
 

CT

77

24.1

5.2

11.4

7.0

−2.6

−2.8

−2.3

8.33·10−30

            
 

TT

53

23.2

4.9

14.8

8.2

−1.7

−2.1

−1.3

1.56·10−12

−0.1

−0.5

0.4

0.764

0.6

0.1

1.1

5.6·10 −3

0.7

0.2

1.1

1.3·10 −3

CGIα

CC

58

5.2

0.7

3.2

1.1

−2.9

−3.3

−2.4

4.85·10−18

            
 

CT

77

5.2

0.8

3.4

1.0

−2.5

−2.9

−2.2

1.77·10−22

            
 

TT

53

5.3

0.7

3.8

1.1

−2.2

−2.6

−1.8

2.08·10−14

0.3

−0.3

0.8

0.150

0.7

0.1

1.3

8.7·10 −3

0.4

−0.1

1.0

0.062+

PASα

CC

58

27.2

10.0

12.4

8.0

−1.5

−1.8

−1.3

5.92·10−17

            
 

CT

75

27.1

10.0

14.1

9.6

−1.3

−1.6

−1.1

4.33·10−16

            
 

TT

53

28.0

10.0

16.2

9.8

−1.2

−1.5

−0.9

8.59·10−12

0.1

−0.2

0.4

0.195

0.3

0.0

0.7

0.017

0.2

−0.1

0.5

0.077+

Panic attacks

CC

58

2.6

2.4

1.1

1.8

−0.4

−0.7

−0.2

1.84·10−03

            
 

CT

78

2.6

2.4

1.0

1.4

−0.5

−0.8

−0.3

3.17·10−05

            
 

TT

53

2.6

2.3

1.5

2.0

−0.3

−0.6

0.0

2.54·10−02

0.1

−0.1

0.3

0.129

0.1

−0.1

0.3

0.101

0.0

−0.1

0.2

0.396

MI

CC

49

2.9

0.9

1.9

0.8

−1.1

−1.4

−0.8

1.09·10−10

            
 

CT

66

2.9

0.7

1.8

0.7

−1.3

−1.5

−1.1

1.33·10−18

            
 

TT

53

3.0

0.9

2.0

0.9

−1.1

−1.4

−0.9

1.23·10−12

−0.2

−0.5

0.1

0.264

0.1

−0.2

0.4

0.347

0.2

−0.1

0.5

0.060+

  1. Treatment effect size displayed as within- and between-groups Cohen’s d based on pre/post CBT score means and baseline standard deviation. Effect size differences based on robust linear regression were corrected for outcome’s baseline values
  2. Significant effect size differences highlighted in bold (p-value < 0.05)
  3. Note that the number of panic attacks in the previous week is also a sub-item of the integrated PAS score
  4. d Cohen’s d effect size, HAM-A Hamilton Anxiety Rating Scale, CGI Clinical Global Impressions Scale, PAS Panic and Agoraphobia Scale, MI Mobility Inventory, CI confidence interval
  5. +Trend-wise significance at p-value < 0.1
  6. α Significant effect size difference in a recessive design (TT vs CC/CT) with reduced treatment response in T allele homozygotes (for full statistical information see Supplementary Table 2)
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