Fig. 4: Interaction effect of Group × Challenge × Expectation in the caudate and midbrain (p < 0.05 small-volume corrected).
From: Expectation effects on brain dopamine responses to methylphenidate in cocaine use disorder
The expectation of methylphenidate (MP) increased MP-induced dopamine (DA) release (PL–MP) in healthy controls (HC) but not in cocaine use disorder (CUD) in whom it tended to reduce it, whereas expectation of PL tended to increase DA release in CUD and decrease in HC. The SPM images were superimposed onto T2-weighted magnetic resonance images in coronal (left upper) and sagittal (right upper) views. The color bar indicates t score values. Red represents the highest value and dark violet represents the lowest value. The bar chart showed DA release (PL–MP) in caudate and midbrain of CUD and HC
