Table 3 Whole-brain results of Group × Expectation for iv-PL > iv-MP

Brain region	L/R	K	MNI (x y z)			t Value
Main effect of Challenge: iv-PL > iv-MP
Putamen	R	4924	30	−6	−4	11.38^a
Putamen	L		−28	−4	−6	10.88^a
Caudate	L	756	−8	12	−12	10.30^b
Caudate	R		10	12	−12	8.96^b
NAc	R	132	10	12	−12	8.96^b
Group × Challenge: CUD < HC, iv-PL > iv-MP
Putamen	R	1086	30	−8	−6	9.74^a
Putamen	L	1110	−28	−8	−6	8.47^a
Caudate	L	163	−14	14	−12	4.85^b
Caudate	R	209	12	16	6	4.43^b
NAc	L	48	−14	14	−12	4.85^b
NAc	R	12	20	12	−12	3.73^b
Expectation × Challenge: Expect PL > Expect MP, iv-PL > iv-MP
No significant voxels
Group × Expectation × Challenge: CUD > HC, Expect PL > Expect MP, iv-PL > iv-MP
Caudate	L	95	−16	−12	22	4.06^b
Midbrain	L	53	−8	−12	−16	3.64^b
	R	43	2	−26	0	3.63^b

BA Brodmann area, CUD cocaine use disorder, HC healthy controls, iv intravenous, K cluster size, L left, MNI (x y z) coordinates in Montreal Neurological Institute space (x y z), MP methylphenidate, NAc nucleus accumbens, PL placebo, R right
^ap < 0.05 family-wise error corrected (FWE) whole brain, cluster-corrected
^bp < 0.05 FWE small-volume corrected

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