Table 1 Baseline characteristics of psychiatric disorder case and control participants

From: Pilot study of DNA methylation, molecular aging markers and measures of health and well-being in aging

Baseline characteristics

Case (n = 11)

Control (n = 12)

p Value

Demographic factors

Age, median (IQR)

67.1 (60.0–74.6)

66.3 (56.4–72.5)

0.56

Sex, n (%)

  

0.68

 Female

7 (63.6)

6 (50.0)

 

 Male

4 (36.4)

6 (50.0)

 

 Race/ethnicity, n (%)

  

0.64

 African-American

2 (18.2)

4 (33.3)

 

 White

9 (81.8)

8 (66.7)

 

 Education, n (%)

College level or less

7 (63.6)

8 (66.7)

0.99

Post-college

4 (36.4)

4 (33.3)

 

 Income, n (%)a

  

0.02

 Lower income, <$50,000/year

7 (87.5)

2 (22.2)

 

 Higher income, ≥$50000/year

1 (12.5)

7 (77.8)

 

Lifestyle and health factors

 Smoking, n (%)

  

0.03

 Never or past smoking

1 (9.1)

7 (58.3)

 

 Current smoking

10 (90.9)

5 (41.7)

 

 Alcohol, n (%)

  

0.64

 Daily use

2 (18.2)

4 (33.3)

 

 All other frequencies of intake

9 (81.8)

8 (66.7)

 

 Obesity, n (%)a

  

0.17

 BMI < 30 kg/m2

5 (50.0)

10 (83.3)

 

 BMI ≥ 30 kg/m2

5 (50.0)

2 (16.7)

 

 Diabetes, n (%)

  

0.32

 Yes

3 (27.3)

1 (8.3)

 

 No

8 (72.7)

11 (91.7)

 

 Hypertension, n (%)

  

0.37

 Yes

9 (81.8)

7 (58.3)

 

 No

2 (18.2)

5 (41.7)

 

 Total exercise (frequency per week), median (IQR)

2.5 (1.0–6.5)

5.5 (2.8–8.5)

0.23

 Physical activity (total met-HR), median (IQR)

10.0 (3.0–21.0)

25.3 (14.7–40.0)

0.1

Cell counts

% Monocytes, median (IQR)

4.80 (3.63–6.63)

5.36 (3.17–7.35)

0.69

% Granulocytes, median (IQR)

71.04 (61.46–77.61)

64.62 (53.06–73.22)

0.2

% Lymphocytes, median (IQR)

32.23 (23.87–39.26)

36.67 (27.69–46.20)

0.35

Molecular aging markers

DNA Methylation age, median (IQR)

59.72 (56.43–66.16)

59.35 (55.72–63.11)

0.65

Telomere length, median (IQR)

0.55 (0.49–0.60)

0.56 (0.51–0.60)

0.61

Mitochondrial copy number, median (IQR)

0.52 (0.31–0.82)

0.54 (0.35–0.63)

0.98

Psychosocial and neurobehavioral variables

PHQ-9, median (IQR)

3.0 (0.0–7.0)

1.0 (0.0–2.5)

0.17

GAD-7, median (IQR)

1.0 (0.0–5.0)

0.5 (0.0–2.0)

0.52

DSSI, median (IQR)

20.0 (15.0–27.0)

26.0 (22.0–28.0)

0.16

STIDA, median (IQR)

1.0 (0.0–3.0)

0.0 (0.0–1.0)

0.39

3MS, median (IQR)

95.0 (90.0–98.0)

94.0 (93.0–98.0)

0.73

Delayed recall z-score, median (IQR)b

−0.3 (−0.6–0.2)

−0.1 (−0.9–0.2)

0.67

  1. IQR interquartile range, BM body mass index, PHQ Patient Health Questionnaire, GAD Generalized Anxiety Disorder, DSSI Duke Social Support Index, STIDA Structured Telephone Interview for Dementia Assessment self-report question score, 3MS Modified Mini-Mental State
  2. aValues shown for participants with non-missing values for income and BMI
  3. bDelayed recall z-score is calculated based on averaging delayed verbal memory recall trials of the East Boston Memory Test paragraph and a 10-word list
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