Fig. 2: Drug classes significantly enriched (FDR or Bonferroni) in major depressive disorder when using the complete annotation set (“all drug-gene connections”), or using only the curated bioactivity set (“curated bioactivities”), which contains ChEMBL and PDSP Ki data. | Translational Psychiatry

Fig. 2: Drug classes significantly enriched (FDR or Bonferroni) in major depressive disorder when using the complete annotation set (“all drug-gene connections”), or using only the curated bioactivity set (“curated bioactivities”), which contains ChEMBL and PDSP Ki data.

From: Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder

Fig. 2

The drug class enrichment was tested using Mann–Whitney–Wilcoxon (MWW) rank tests, on drugs ordered by MAGMA pathway analysis p-value. The Bonferroni correction is based on the number of tested classes: 57 for the curated bioactivity set, 141 for the complete connection set

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