Fig. 3: Drug-target network from the online tool Drug Targetor (drugtargetor.com), showing the top drugs and their top-classified targets/genes for MDD in the Nervous System, ordered by genetic scores. | Translational Psychiatry

Fig. 3: Drug-target network from the online tool Drug Targetor (drugtargetor.com), showing the top drugs and their top-classified targets/genes for MDD in the Nervous System, ordered by genetic scores.

From: Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder

Fig. 3

The drug association statistics in −log10(P) units were obtained using MAGMA pathway analysis, and the gene associations using MAGMA gene-wise analysis. Expression z-scores obtained by S-PrediXcan in the different tissues are colored in green for positive effect, red for negative effect. Drug/target connections are colored by drug action type

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