Table 2 Hub targets in drug-target networks, with human (H) or mouse (M) phenotypes identified in the HDMC (human-mouse disease connection database)

DRD2

Dopamine receptor D2

***

H/M

H/M

Drugs for gastrointestinal disorders, psycholeptics, antipsychotics, psychoanaleptics

HTR1D

Serotonin receptor 5-HT1D

**

Normal mouse phenotype

Normal mouse phenotype

Antipsychotics, analgesics (triptans)

CACNA2D1

Calcium channel subunit

***

M

M

Calcium channel blockers/modulators

CACNA1H

Calcium channel subunit

**

M

H/M

Calcium channel blockers/modulators

ESR2

Estrogen receptor ER-β

***

H/M

H/M

Hormones and modulators of the genital system

CHRM3

Cholinergic/acetylcholine receptor M3

*

M

H/M

Drugs for gastrointestinal disorders, antipsychotics, psychoanaleptics

ESR1

Estrogen receptor ER-α

*

H/M

H/M

Hormones and modulators of the genital system

GABRA1

GABA-A receptor subunit

*

M

H/M

Anesthetics, psycholeptics

GABRG3

GABA-A receptor subunit

*

–

–

Anesthetics, psycholeptics

GABRA6

GABA-A receptor subunit

*

M

M

Anesthetics, psycholeptics

HRH1

Histamine H1 receptor

*

M

–

Antihistamines, antipsychotics, psychoanaleptics

GRIA1

Glutamate receptor 1

*

M

M

Anesthetics

CACNA1C

Calcium channel subunit

*

M

H/M

Calcium channel blockers/modulators