Table 1 SECA results for TS whole cohort

From: Concordance of genetic variation that increases risk for Tourette Syndrome and that influences its underlying neurocircuitry

Trait 1

Trait 2

p-value pleiotropy

CI pleiotropy

p-value concordance

CI concordance

Direction

TS

Intracranial volume

0.001**

0.001–0.002

0.022**

0.019–0.025

–

Accumbens

0.007**

0.006–0.009

0.054*

0.049–0.058

–

Amygdala

1

1–1

0.048**

0.044–0.053

+

Caudate

4 × 10−4***

1 × 10−4–0.001

0.016**

0.013–0.018

–

Hippocampus

0.009**

0.007–0.011

0.07*

0.065–0.075

+

Pallidum

0.006**

0.004–0.007

0.257

0.249–0.266

–

Putamen

2 × 10−4***

5.48 × 10−5–0.007

1

1–1

–

Thalamus

0.009**

0.008–0.012

3 × 10−4***

1 × 10−4–0.001

–

  1. TS Tourette’s syndrome, CI confidence interval, Bonferroni corrected p-value = 0.05/48 = 1.042 × 10−3
  2. *Trending significance (p < 0.1)
  3. **Nominally significant (p < 0.05)
  4. ***Significant
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