Table 2 SECA results for TS social disinhibition endophenotype

From: Concordance of genetic variation that increases risk for Tourette Syndrome and that influences its underlying neurocircuitry

Trait 1

Trait 2

p-value pleiotropy

CI pleiotropy

p-value concordance

CI concordance

Direction

TS

Intracranial volume

1

1–1

1

1–1

+

Accumbens

0.31

0.301–0.319

0.002**

0.002–0.003

–

Amygdala

0.166

0.159–0.173

0.084*

0.079–0.09

–

Caudate

1

1–1

0.166

0.159–0.173

–

Hippocampus

1

1–1

0.099*

0.093–0.105

–

Pallidum

1

1–1

0.047**

0.043–0.051

+

Putamen

1

1–1

0.194

0.186–0.201

–

Thalamus

1

1–1

1 × 10−3***

5.13e−06–0.001

–

  1. TS Tourette’s syndrome, CI confidence interval, Bonferroni corrected p-value = 0.05/48 = 1.042 × 10−3
  2. *Trending significance (p < 0.1)
  3. **Nominally significant (p < 0.05)
  4. ***Significant
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