Table 3 SECA results for TS symmetry endophenotype

From: Concordance of genetic variation that increases risk for Tourette Syndrome and that influences its underlying neurocircuitry

Trait 1

Trait 2

p-value pleiotropy

CI pleiotropy

p-value concordance

CI concordance

Direction

TS

Intracranial volume

1

1–1

0.191

0.183–0.198

–

Accumbens

0.304

0.296–0.314

0.263

0.255–0.272

–

Amygdala

0.298

0.289–0.307

0.002**

0.001–0.003

–

Caudate

0.304

0.295–0.313

0.017**

0.015–0.02

+

Hippocampus

1

1–1

0.07*

0.065–0.075

+

Pallidum

1

1–1

0.417

0.408–0.427

+

Putamen

0.313

0.304–0.322

0.001***

0–0.001

+

Thalamus

1

1–1

1

1–1

–

  1. TS Tourette’s syndrome, CI confidence interval, Bonferroni corrected p-value = 0.05/48 = 1.042 × 10−3
  2. *Trending significance (p < 0.1)
  3. **Nominally significant (p < 0.05)
  4. ***Significant
Back to article page