Table 5 Conditional FDR results for TS and endophenotypes with brain volume overlap

From: Concordance of genetic variation that increases risk for Tourette Syndrome and that influences its underlying neurocircuitry

Structure

SNP

Chr

BP

EA

NEA

Freq

Nearest gene

Distance to gene (bp)

Effect in brain ± standard error

p-value in brain

% Variance explained in brain

Effect in TS ± standard error

p-value in TS

% Variance explained in TS

q-value

Intracranial volume

rs2708146

2

58955953

A

G

0.5428

LINC01122

Intronic

484.913 ± 1901.256

0.799

5.72 × 10−4

0.141 ± 0.027

1.3 × 10−7

0.2089

0.046

rs72853320

6

36623338

A

G

0.1331

RNU1-88P

15889

−3769.398 ± 2836.113

0.184

0.0155

0.205 ± 0.04

2.42 × 10−7

0.1997

0.035

Hippocampus

rs1922786

2

58863573

A

G

0.6556

LINC01122

Intronic

−17.527 ± 4.895

0

9.62 × 10−5

0.14 ± 0.028

7.93 × 10−7

0.1828

0.001

  1. The chromosome (Chr) and base pair (BP) are given in h19b37 coordinates. The effect in brain and effect in TS (Tourette’s syndrome) are both given in terms of the effect allele (EA). The non-effect allele (NEA) is also shown. The allele frequency (Freq) corresponds to the effect allele. Tagging SNP corresponds to the most significant variant in a given LD block (if different from the SNP chosen based on clumping in the brain volume GWAS). LINC01122 = long intergenic non-protein coding RNA 1122, RNU1-88P = RNA, U1 small nuclear 88, pseudogene
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